RcisTarget R Package: Transcription factor binding motif enrichment
Overview of RcisTarget R Package
RcisTarget identifies transcription factor binding motifs (TFBS) over-represented on a gene list. In a first step, RcisTarget selects DNA motifs that are significantly over-represented in the surroundings of the transcription start site (TSS) of the genes in the gene-set. This is achieved by using a database that contains genome-wide cross-species rankings for each motif. The motifs that are then annotated to TFs and those that have a high Normalized Enrichment Score (NES) are retained. Finally, for each motif and gene-set, RcisTarget predicts the candidate target genes (i.e. genes in the gene-set that are ranked above the leading edge). For additional details about RcisTarget package, please refer Reference Paper 1, R Package 1, and R Package 1 vignettes
Brief instructions about application of the RcisTarget R package on Generation 3 Modules
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The RcisTarget R script was applied on all 382 Generation 3 modules Reference Paper 2 using the default settings.
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The input data are *.txt files containing Gene Symbol column as mandatory.
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The output data (see table below) of this analysis is Motif_Enrichment_AUC_Histogram_Plot.pdf, Best_Enrichment_Motifs_NES_Plot.pdf, motifEnrichmentTable.csv, motifEnrichmentTable_wGenes.csv, Motif_data_table.html, and Network.html. For more details about the outputs (plots, data tables), refer the documentation link provided above.
Note:
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All the plots and csv files can be opened by a simple left click and viewed in RcisTarget Advanced Data Analysis column (see below), however, Motif_data_table.html and Network.html cannot be viewed by a simple left click. To view the interactive Motif data table and Network for the appropriate module, click on the link under each column provided below
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Best_Enrichment_Motifs_NES_Plot.pdf and Network.html outputs are only the outputs of subset data (considering the top 3 best motif enrichments). This is because the size of the output files and limitation of storage space. However, it is worth noting it is possible to include all motifs while performing the analysis. This generates larger data files, requires more storage space and more computation
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In summary, from RcisTarget analysis, outputs were obtained for a total of 235 modules successfully, however, 147 modules failed to run (due to non-matching Gene Symbol identifier between the input file and motif database). Hence, no results will be found for these modules.
Module Analysis Result Table
| Module ID | Module Annotation | Number of unique genes | RcisTarget- Advanced Data Analysis | RcisTarget- Motif Data Table | RcisTarget- Network Analysis |
|---|---|---|---|---|---|
| M3.1 | Cell cycle | 106 | No Result | No Result | No Result |
| M8.1 | TBD | 51 | No Result | No Result | No Result |
| M8.2 | Prostanoids | 36 | Link | Link | Link |
| M8.3 | Type 1 Interferon | 17 | Link | Link | Link |
| M9.1 | Cytotoxic lymphocytes | 28 | Link | Link | Link |
| M9.2 | Erythrocytes | 30 | Link | Link | Link |
| M10.1 | Interferon | 21 | Link | Link | Link |
| M10.2 | Protein synthesis | 19 | Link | Link | Link |
| M10.3 | Platelet | 20 | Link | Link | Link |
| M10.4 | Neutrophil activation | 13 | No Result | No Result | No Result |
| M11.1 | Protein synthesis | 46 | No Result | No Result | No Result |
| M11.2 | TBD | 39 | Link | Link | Link |
| M11.3 | Erythrocytes | 24 | Link | Link | Link |
| M11.4 | TBD | 26 | Link | Link | Link |
| M12.1 | Protein modification | 111 | Link | Link | Link |
| M12.2 | Monocytes | 44 | Link | Link | Link |
| M12.3 | Cell cycle | 70 | Link | Link | Link |
| M12.4 | Gene transcription | 62 | Link | Link | Link |
| M12.5 | Protein modification | 91 | Link | Link | Link |
| M12.6 | T cells | 33 | Link | Link | Link |
| M12.7 | Protein synthesis | 35 | No Result | No Result | No Result |
| M12.8 | B cells | 26 | Link | Link | Link |
| M12.9 | Protein phosphorylation | 42 | Link | Link | Link |
| M12.10 | Inflammation | 53 | Link | Link | Link |
| M12.11 | Erythrocytes | 24 | No Result | No Result | No Result |
| M12.12 | Oxidative stress | 31 | No Result | No Result | No Result |
| M12.13 | Oxidative phosphorylation | 47 | Link | Link | Link |
| M12.14 | TBD | 20 | No Result | No Result | No Result |
| M12.15 | Cell cycle | 17 | Link | Link | Link |
| M13.1 | Inflammation | 137 | Link | Link | Link |
| M13.2 | Gene transcription | 92 | Link | Link | Link |
| M13.3 | TBD | 100 | Link | Link | Link |
| M13.4 | Protein synthesis | 119 | Link | Link | Link |
| M13.5 | Cell death | 134 | Link | Link | Link |
| M13.6 | Gene transcription | 127 | Link | Link | Link |
| M13.7 | TBD | 98 | Link | Link | Link |
| M13.8 | TBD | 55 | No Result | No Result | No Result |
| M13.9 | Gene transcription | 99 | Link | Link | Link |
| M13.10 | Protein synthesis | 91 | No Result | No Result | No Result |
| M13.11 | TBD | 78 | Link | Link | Link |
| M13.12 | Inflammation | 55 | Link | Link | Link |
| M13.13 | Gene transcription | 58 | No Result | No Result | No Result |
| M13.14 | Proteolysis | 72 | Link | Link | Link |
| M13.15 | Gene transcription | 76 | Link | Link | Link |
| M13.16 | Cytokines/chemokines | 39 | Link | Link | Link |
| M13.17 | Interferon | 31 | Link | Link | Link |
| M13.18 | B cells | 88 | Link | Link | Link |
| M13.19 | Protein phosphorylation | 63 | Link | Link | Link |
| M13.20 | Cell cycle | 47 | No Result | No Result | No Result |
| M13.21 | Cytotoxic lymphocytes | 23 | Link | Link | Link |
| M13.22 | Neutrophils | 65 | Link | Link | Link |
| M13.23 | TBD | 79 | Link | Link | Link |
| M13.24 | TBD | 70 | Link | Link | Link |
| M13.25 | Protein phosphorylation | 79 | Link | Link | Link |
| M13.26 | Oxidative stress | 40 | Link | Link | Link |
| M13.27 | B cells | 33 | Link | Link | Link |
| M13.28 | Protein synthesis | 29 | No Result | No Result | No Result |
| M13.29 | Protein modification | 65 | Link | Link | Link |
| M13.30 | Erythrocytes | 29 | Link | Link | Link |
| M13.31 | TBD | 25 | Link | Link | Link |
| M13.32 | Cell cycle | 30 | Link | Link | Link |
| M14.1 | Gene transcription | 44 | Link | Link | Link |
| M14.2 | Protein synthesis | 44 | Link | Link | Link |
| M14.3 | Protein modification | 39 | Link | Link | Link |
| M14.4 | Gene transcription | 38 | Link | Link | Link |
| M14.5 | Gene transcription | 36 | No Result | No Result | No Result |
| M14.6 | TBD | 31 | No Result | No Result | No Result |
| M14.7 | TBD | 31 | Link | Link | Link |
| M14.8 | TBD | 30 | Link | Link | Link |
| M14.9 | TBD | 27 | Link | Link | Link |
| M14.10 | TBD | 28 | Link | Link | Link |
| M14.11 | TBD | 28 | Link | Link | Link |
| M14.12 | Cell cycle | 26 | Link | Link | Link |
| M14.13 | Oxidative phosphorylation | 26 | Link | Link | Link |
| M14.14 | Protein modification | 27 | Link | Link | Link |
| M14.15 | Protein modification | 25 | Link | Link | Link |
| M14.16 | TBD | 26 | Link | Link | Link |
| M14.17 | Gene transcription | 26 | Link | Link | Link |
| M14.18 | TBD | 25 | Link | Link | Link |
| M14.19 | Inflammation | 23 | Link | Link | Link |
| M14.20 | Gene transcription | 24 | Link | Link | Link |
| M14.21 | TBD | 23 | Link | Link | Link |
| M14.22 | TBD | 23 | Link | Link | Link |
| M14.23 | Gene transcription | 24 | Link | Link | Link |
| M14.24 | Inflammation | 23 | Link | Link | Link |
| M14.25 | TBD | 22 | Link | Link | Link |
| M14.26 | Inflammation | 22 | Link | Link | Link |
| M14.27 | Protein synthesis | 21 | No Result | No Result | No Result |
| M14.28 | Neutrophils | 20 | Link | Link | Link |
| M14.29 | TBD | 22 | Link | Link | Link |
| M14.30 | Oxidative phosphorylation | 21 | Link | Link | Link |
| M14.31 | Cell cycle | 22 | Link | Link | Link |
| M14.32 | TBD | 22 | Link | Link | Link |
| M14.33 | Proteolysis | 22 | No Result | No Result | No Result |
| M14.34 | Gene transcription | 21 | Link | Link | Link |
| M14.35 | TBD | 20 | Link | Link | Link |
| M14.36 | TBD | 20 | Link | Link | Link |
| M14.37 | TBD | 19 | Link | Link | Link |
| M14.38 | TBD | 17 | Link | Link | Link |
| M14.39 | Cell cycle | 18 | Link | Link | Link |
| M14.40 | Cellular respiration | 19 | Link | Link | Link |
| M14.41 | TBD | 19 | Link | Link | Link |
| M14.42 | T cells | 19 | Link | Link | Link |
| M14.43 | TBD | 18 | Link | Link | Link |
| M14.44 | Protein synthesis | 18 | Link | Link | Link |
| M14.45 | TBD | 18 | No Result | No Result | No Result |
| M14.46 | TBD | 18 | Link | Link | Link |
| M14.47 | Protein synthesis | 18 | No Result | No Result | No Result |
| M14.48 | Inflammation | 17 | Link | Link | Link |
| M14.49 | Gene transcription | 18 | No Result | No Result | No Result |
| M14.50 | Inflammation | 18 | Link | Link | Link |
| M14.51 | Oxidative stress | 14 | Link | Link | Link |
| M14.52 | TBD | 17 | Link | Link | Link |
| M14.53 | Erythrocytes | 16 | Link | Link | Link |
| M14.54 | Cell cycle | 18 | No Result | No Result | No Result |
| M14.55 | Gene transcription | 17 | Link | Link | Link |
| M14.56 | TBD | 17 | Link | Link | Link |
| M14.57 | Protein modification | 16 | Link | Link | Link |
| M14.58 | Protein synthesis | 17 | No Result | No Result | No Result |
| M14.59 | TBD | 16 | Link | Link | Link |
| M14.60 | TBD | 17 | Link | Link | Link |
| M14.61 | Protein modification | 16 | Link | Link | Link |
| M14.62 | TBD | 16 | Link | Link | Link |
| M14.63 | Oxidative phosphorylation | 16 | Link | Link | Link |
| M14.64 | Cell cycle | 16 | Link | Link | Link |
| M14.65 | Monocytes | 15 | Link | Link | Link |
| M14.66 | Inflammation | 16 | Link | Link | Link |
| M14.67 | Gene transcription | 16 | Link | Link | Link |
| M14.68 | Protein synthesis | 16 | Link | Link | Link |
| M14.69 | Gene transcription | 15 | Link | Link | Link |
| M14.70 | TBD | 15 | Link | Link | Link |
| M14.71 | Gene transcription | 14 | No Result | No Result | No Result |
| M14.72 | TBD | 15 | Link | Link | Link |
| M14.73 | TBD | 15 | Link | Link | Link |
| M14.74 | TBD | 14 | Link | Link | Link |
| M14.75 | Protein synthesis | 15 | No Result | No Result | No Result |
| M14.76 | Leukocyte activation | 15 | Link | Link | Link |
| M14.77 | Gene transcription | 15 | Link | Link | Link |
| M14.78 | TBD | 15 | Link | Link | Link |
| M14.79 | Protein synthesis | 15 | Link | Link | Link |
| M14.80 | Protein synthesis | 12 | No Result | No Result | No Result |
| M14.81 | Platelet | 14 | No Result | No Result | No Result |
| M14.82 | Cytokines/chemokines | 15 | Link | Link | Link |
| M14.83 | TBD | 14 | Link | Link | Link |
| M15.1 | TBD | 79 | Link | Link | Link |
| M15.2 | TBD | 60 | Link | Link | Link |
| M15.3 | Gene transcription | 57 | No Result | No Result | No Result |
| M15.4 | B cells | 54 | No Result | No Result | No Result |
| M15.5 | Protein modification | 53 | Link | Link | Link |
| M15.6 | Cell cycle | 54 | Link | Link | Link |
| M15.7 | Monocytes | 52 | Link | Link | Link |
| M15.8 | Gene transcription | 51 | No Result | No Result | No Result |
| M15.9 | T cells | 51 | No Result | No Result | No Result |
| M15.10 | Gene transcription | 50 | Link | Link | Link |
| M15.11 | TBD | 49 | No Result | No Result | No Result |
| M15.12 | TBD | 48 | Link | Link | Link |
| M15.13 | TBD | 48 | Link | Link | Link |
| M15.14 | TBD | 47 | No Result | No Result | No Result |
| M15.15 | TBD | 46 | Link | Link | Link |
| M15.16 | Antigen presentation | 45 | No Result | No Result | No Result |
| M15.17 | TBD | 44 | No Result | No Result | No Result |
| M15.18 | TBD | 41 | Link | Link | Link |
| M15.19 | Gene transcription | 43 | No Result | No Result | No Result |
| M15.20 | TBD | 41 | Link | Link | Link |
| M15.21 | Gene transcription | 42 | Link | Link | Link |
| M15.22 | TBD | 42 | Link | Link | Link |
| M15.23 | Cell death | 41 | Link | Link | Link |
| M15.24 | TBD | 41 | Link | Link | Link |
| M15.25 | TBD | 38 | Link | Link | Link |
| M15.26 | Neutrophils | 38 | Link | Link | Link |
| M15.27 | Cell cycle | 40 | No Result | No Result | No Result |
| M15.28 | Oxidative phosphorylation | 37 | No Result | No Result | No Result |
| M15.29 | Cell death | 35 | No Result | No Result | No Result |
| M15.30 | TBD | 36 | Link | Link | Link |
| M15.31 | Protein modification | 35 | Link | Link | Link |
| M15.32 | TBD | 36 | No Result | No Result | No Result |
| M15.33 | T cells | 35 | No Result | No Result | No Result |
| M15.34 | T cells | 34 | Link | Link | Link |
| M15.35 | Neutrophils | 33 | Link | Link | Link |
| M15.36 | Protein modification | 34 | Link | Link | Link |
| M15.37 | Inflammation | 33 | Link | Link | Link |
| M15.38 | T cells | 32 | No Result | No Result | No Result |
| M15.39 | TBD | 32 | Link | Link | Link |
| M15.40 | Gene transcription | 31 | No Result | No Result | No Result |
| M15.41 | TBD | 31 | Link | Link | Link |
| M15.42 | Gene transcription | 30 | Link | Link | Link |
| M15.43 | TBD | 30 | Link | Link | Link |
| M15.44 | Protein modification | 28 | No Result | No Result | No Result |
| M15.45 | Platelet | 29 | Link | Link | Link |
| M15.46 | TBD | 27 | Link | Link | Link |
| M15.47 | Antigen presentation | 28 | Link | Link | Link |
| M15.48 | TBD | 27 | No Result | No Result | No Result |
| M15.49 | Cell death | 27 | No Result | No Result | No Result |
| M15.50 | TBD | 27 | Link | Link | Link |
| M15.51 | Protein synthesis | 26 | No Result | No Result | No Result |
| M15.52 | TBD | 27 | No Result | No Result | No Result |
| M15.53 | Erythrocytes | 25 | Link | Link | Link |
| M15.54 | TBD | 26 | No Result | No Result | No Result |
| M15.55 | Protein phosphorylation | 24 | Link | Link | Link |
| M15.56 | Cell adhesion | 25 | No Result | No Result | No Result |
| M15.57 | TBD | 26 | Link | Link | Link |
| M15.58 | Monocytes | 22 | No Result | No Result | No Result |
| M15.59 | TBD | 24 | No Result | No Result | No Result |
| M15.60 | TBD | 25 | No Result | No Result | No Result |
| M15.61 | Monocytes | 25 | Link | Link | Link |
| M15.62 | TBD | 25 | No Result | No Result | No Result |
| M15.63 | TBD | 22 | Link | Link | Link |
| M15.64 | Interferon | 21 | Link | Link | Link |
| M15.65 | TBD | 23 | Link | Link | Link |
| M15.66 | TBD | 23 | Link | Link | Link |
| M15.67 | TBD | 22 | No Result | No Result | No Result |
| M15.68 | TBD | 23 | No Result | No Result | No Result |
| M15.69 | TBD | 22 | Link | Link | Link |
| M15.70 | Protein modification | 22 | Link | Link | Link |
| M15.71 | TBD | 22 | Link | Link | Link |
| M15.72 | TBD | 22 | Link | Link | Link |
| M15.73 | Cell cycle | 22 | No Result | No Result | No Result |
| M15.74 | Erythrocytes | 21 | No Result | No Result | No Result |
| M15.75 | TBD | 20 | Link | Link | Link |
| M15.76 | TBD | 21 | Link | Link | Link |
| M15.77 | TBD | 21 | No Result | No Result | No Result |
| M15.78 | TBD | 20 | No Result | No Result | No Result |
| M15.79 | Mitochondrial Stress/Proteasome | 19 | Link | Link | Link |
| M15.80 | TBD | 20 | Link | Link | Link |
| M15.81 | TBD | 20 | Link | Link | Link |
| M15.82 | TBD | 20 | Link | Link | Link |
| M15.83 | Gene transcription | 20 | No Result | No Result | No Result |
| M15.84 | Cytokines/chemokines | 20 | No Result | No Result | No Result |
| M15.85 | TBD | 20 | No Result | No Result | No Result |
| M15.86 | Interferon | 15 | Link | Link | Link |
| M15.87 | TBD | 19 | No Result | No Result | No Result |
| M15.88 | TBD | 19 | No Result | No Result | No Result |
| M15.89 | TBD | 19 | No Result | No Result | No Result |
| M15.90 | TBD | 16 | Link | Link | Link |
| M15.91 | TBD | 17 | Link | Link | Link |
| M15.92 | Protein modification | 18 | No Result | No Result | No Result |
| M15.93 | TBD | 18 | No Result | No Result | No Result |
| M15.94 | TBD | 18 | Link | Link | Link |
| M15.95 | TBD | 18 | No Result | No Result | No Result |
| M15.96 | TBD | 18 | Link | Link | Link |
| M15.97 | Cell death | 17 | No Result | No Result | No Result |
| M15.98 | T cells | 18 | Link | Link | Link |
| M15.99 | Protein modification | 15 | Link | Link | Link |
| M15.100 | Erythrocytes | 17 | Link | Link | Link |
| M15.101 | TBD | 18 | Link | Link | Link |
| M15.102 | Prostanoids | 15 | Link | Link | Link |
| M15.103 | TBD | 17 | Link | Link | Link |
| M15.104 | TBD | 17 | Link | Link | Link |
| M15.105 | Inflammation | 16 | Link | Link | Link |
| M15.106 | TBD | 17 | Link | Link | Link |
| M15.107 | TBD | 17 | Link | Link | Link |
| M15.108 | TBD | 17 | Link | Link | Link |
| M15.109 | Inflammation | 17 | No Result | No Result | No Result |
| M15.110 | Cell cycle | 16 | Link | Link | Link |
| M15.111 | TBD | 17 | No Result | No Result | No Result |
| M15.112 | TBD | 16 | Link | Link | Link |
| M15.113 | Inflammation | 16 | No Result | No Result | No Result |
| M15.114 | TBD | 16 | No Result | No Result | No Result |
| M15.115 | TBD | 16 | No Result | No Result | No Result |
| M15.116 | TBD | 16 | No Result | No Result | No Result |
| M15.117 | TBD | 16 | No Result | No Result | No Result |
| M15.118 | Gene transcription | 14 | Link | Link | Link |
| M15.119 | TBD | 16 | No Result | No Result | No Result |
| M15.120 | TBD | 16 | No Result | No Result | No Result |
| M15.121 | TBD | 14 | Link | Link | Link |
| M15.122 | TBD | 15 | No Result | No Result | No Result |
| M15.123 | TBD | 15 | Link | Link | Link |
| M15.124 | TBD | 15 | Link | Link | Link |
| M15.125 | TBD | 15 | Link | Link | Link |
| M15.126 | Gene transcription | 15 | Link | Link | Link |
| M15.127 | Interferon | 14 | No Result | No Result | No Result |
| M16.1 | TBD | 169 | Link | Link | Link |
| M16.2 | Protein synthesis | 161 | Link | Link | Link |
| M16.3 | T cells | 145 | Link | Link | Link |
| M16.4 | TBD | 130 | No Result | No Result | No Result |
| M16.5 | TBD | 123 | Link | Link | Link |
| M16.6 | Monocytes | 119 | No Result | No Result | No Result |
| M16.7 | TBD | 116 | Link | Link | Link |
| M16.8 | TBD | 116 | Link | Link | Link |
| M16.9 | Protein modification | 109 | Link | Link | Link |
| M16.10 | TBD | 105 | No Result | No Result | No Result |
| M16.11 | Protein synthesis | 102 | No Result | No Result | No Result |
| M16.12 | B cells | 100 | No Result | No Result | No Result |
| M16.13 | Protein modification | 94 | No Result | No Result | No Result |
| M16.14 | TBD | 89 | Link | Link | Link |
| M16.15 | Cell death | 86 | No Result | No Result | No Result |
| M16.16 | TBD | 88 | No Result | No Result | No Result |
| M16.17 | Gene transcription | 83 | No Result | No Result | No Result |
| M16.18 | TBD | 82 | No Result | No Result | No Result |
| M16.19 | TBD | 82 | No Result | No Result | No Result |
| M16.20 | TBD | 81 | No Result | No Result | No Result |
| M16.21 | TBD | 80 | No Result | No Result | No Result |
| M16.22 | TBD | 76 | No Result | No Result | No Result |
| M16.23 | Cell cycle | 76 | Link | Link | Link |
| M16.24 | T cells | 72 | Link | Link | Link |
| M16.25 | TBD | 74 | No Result | No Result | No Result |
| M16.26 | TBD | 72 | Link | Link | Link |
| M16.27 | TBD | 69 | Link | Link | Link |
| M16.28 | TBD | 67 | No Result | No Result | No Result |
| M16.29 | TBD | 62 | Link | Link | Link |
| M16.30 | Complement | 61 | No Result | No Result | No Result |
| M16.31 | TBD | 62 | No Result | No Result | No Result |
| M16.32 | TBD | 59 | Link | Link | Link |
| M16.33 | TBD | 59 | No Result | No Result | No Result |
| M16.34 | Gene transcription | 56 | No Result | No Result | No Result |
| M16.35 | TBD | 55 | No Result | No Result | No Result |
| M16.36 | Gene transcription | 54 | Link | Link | Link |
| M16.37 | TBD | 48 | No Result | No Result | No Result |
| M16.38 | TBD | 52 | No Result | No Result | No Result |
| M16.39 | TBD | 52 | No Result | No Result | No Result |
| M16.40 | Monocytes | 51 | No Result | No Result | No Result |
| M16.41 | TBD | 48 | No Result | No Result | No Result |
| M16.42 | TBD | 50 | No Result | No Result | No Result |
| M16.43 | Gene transcription | 48 | No Result | No Result | No Result |
| M16.44 | Protein synthesis | 48 | Link | Link | Link |
| M16.45 | TBD | 47 | Link | Link | Link |
| M16.46 | TBD | 48 | No Result | No Result | No Result |
| M16.47 | TNF | 47 | No Result | No Result | No Result |
| M16.48 | TBD | 47 | No Result | No Result | No Result |
| M16.49 | Inflammation | 45 | No Result | No Result | No Result |
| M16.50 | Protein modification | 45 | No Result | No Result | No Result |
| M16.51 | Protein synthesis | 43 | No Result | No Result | No Result |
| M16.52 | Lymphocyte | 43 | Link | Link | Link |
| M16.53 | TBD | 42 | No Result | No Result | No Result |
| M16.54 | TBD | 40 | Link | Link | Link |
| M16.55 | TBD | 40 | No Result | No Result | No Result |
| M16.56 | Protein synthesis | 38 | No Result | No Result | No Result |
| M16.57 | B cells | 38 | No Result | No Result | No Result |
| M16.58 | TBD | 39 | No Result | No Result | No Result |
| M16.59 | TBD | 38 | No Result | No Result | No Result |
| M16.60 | Cell cycle | 36 | Link | Link | Link |
| M16.61 | TBD | 36 | Link | Link | Link |
| M16.62 | TBD | 35 | No Result | No Result | No Result |
| M16.63 | TBD | 35 | Link | Link | Link |
| M16.64 | Platelet/Prostaglandin | 33 | Link | Link | Link |
| M16.65 | TGF-beta | 34 | Link | Link | Link |
| M16.66 | TBD | 34 | No Result | No Result | No Result |
| M16.67 | TBD | 33 | No Result | No Result | No Result |
| M16.68 | Protein synthesis | 33 | Link | Link | Link |
| M16.69 | Lipid metabolism | 32 | Link | Link | Link |
| M16.70 | TBD | 29 | Link | Link | Link |
| M16.71 | TBD | 31 | Link | Link | Link |
| M16.72 | TBD | 30 | Link | Link | Link |
| M16.73 | Protein synthesis | 30 | Link | Link | Link |
| M16.74 | TBD | 29 | No Result | No Result | No Result |
| M16.75 | Cell death | 30 | No Result | No Result | No Result |
| M16.76 | TBD | 25 | Link | Link | Link |
| M16.77 | Antigen presentation | 28 | No Result | No Result | No Result |
| M16.78 | B cells | 28 | No Result | No Result | No Result |
| M16.79 | Protein synthesis | 27 | Link | Link | Link |
| M16.80 | Cytokines/chemokines | 27 | No Result | No Result | No Result |
| M16.81 | TBD | 27 | No Result | No Result | No Result |
| M16.82 | Gene transcription | 25 | No Result | No Result | No Result |
| M16.83 | Cell adhesion | 26 | Link | Link | Link |
| M16.84 | Protein phosphorylation | 25 | Link | Link | Link |
| M16.85 | TBD | 24 | Link | Link | Link |
| M16.86 | Oxidative stress | 25 | No Result | No Result | No Result |
| M16.87 | TBD | 23 | No Result | No Result | No Result |
| M16.88 | Erythrocytes | 23 | No Result | No Result | No Result |
| M16.89 | TBD | 23 | No Result | No Result | No Result |
| M16.90 | TBD | 22 | No Result | No Result | No Result |
| M16.91 | TBD | 21 | Link | Link | Link |
| M16.92 | Cell cycle | 22 | Link | Link | Link |
| M16.93 | TBD | 22 | No Result | No Result | No Result |
| M16.94 | TBD | 21 | No Result | No Result | No Result |
| M16.95 | B cells | 21 | No Result | No Result | No Result |
| M16.96 | Erythrocytes | 19 | Link | Link | Link |
| M16.97 | Cell death | 20 | Link | Link | Link |
| M16.98 | TBD | 18 | No Result | No Result | No Result |
| M16.99 | Protein modification | 17 | Link | Link | Link |
| M16.100 | TBD | 18 | No Result | No Result | No Result |
| M16.101 | TBD | 17 | Link | Link | Link |
| M16.102 | TBD | 17 | Link | Link | Link |
| M16.103 | TBD | 17 | No Result | No Result | No Result |
| M16.104 | Cell cycle | 17 | No Result | No Result | No Result |
| M16.105 | TBD | 17 | No Result | No Result | No Result |
| M16.106 | TBD | 15 | No Result | No Result | No Result |
| M16.107 | Oxidative stress | 16 | No Result | No Result | No Result |
| M16.108 | TBD | 16 | No Result | No Result | No Result |
| M16.109 | Platelet | 15 | Link | Link | Link |
| M16.110 | TBD | 15 | No Result | No Result | No Result |
| M16.111 | TBD | 15 | Link | Link | Link |